Varsity-Scholarship internet advertisement

Subscribe to Varsity-scholarship.com

The best source of heme iron  for the brain

How the Brain Source for iron, the best source of heme iron for the brain: iron distribution within the brain is diverse in character or content and the highest concentrations are found in the mid brain, which reaches levels comparable to the liver. Ageing in healthy individuals is accompanied by iron accumulation in several brain regions, with iron accumulation mainly bound to ferritin and neuromelanin. However, several neurodegenerative disorders are also characterised by increases in brain iron levels in specific regions, which is accompanied by brain cellular damage and oxidative stress.

High expression levels of molecules that take up transferrin mediate the iron uptake in the brain. Some scientist believes that transferrin is transported into endosomes across the brain blood vessel liquid compartment and is directly released into the brain others believe that iron is released from endosomes in the brain blood vessel liquid compartment and exported into the brain through ferroportin.  Some model proposes brain blood vessel as a site of regulation of brain iron through regulation of transferrin.  Although transferrin is considered as the major iron transport and delivery protein in the periphery and it is the primary iron mode of acquiring iron in the brain, iron level in the brain is not dependent on iron levels in the periphery. The buffering ability of transferrin in the brain is very small and additional mechanisms for iron binding and storage are used by the brain to protect neurones from excess iron.

The best source of heme iron  for the brain: High expression levels of molecules that take up transferrin mediate the iron uptake in the brain. Hamel et al., 2006
The best source of heme iron for the brain: High expression levels of molecules that take up transferrin mediate the iron uptake in the brain. Hamel et al., 2006

In the normal adult brain, oligodendrocytes which produce myelin are the main cells that stain for iron. During brain development, iron staining is detected as ferritin in microglia, but as the brain matures, ferritin staining is shifted from microglia to oligodendrocytes which suggest ferritin as a source of iron in the brain.

http://varsity-scholarship.com/blog/wp-content/uploads/2016/10/brain-min-1.jpghttp://varsity-scholarship.com/blog/wp-content/uploads/2016/10/brain-min-1-150x150.jpgVarsityAcademic HealthScholarship InformationsAcademic HealthThe best source of heme iron  for the brain How the Brain Source for iron, the best source of heme iron for the brain: iron distribution within the brain is diverse in character or content and the highest concentrations are found in the mid brain, which reaches levels comparable to...We are scholarship people

Topic Related Comments and Discussion. Please Share information. Regards

comments

Varsity-scholarship marketing advertisement

Subscribe to Varsity-scholarship.com